Author Topic: clustered regularly interspaced short palindromic repeats - CRISPR  (Read 7984 times)

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Offline Jackson Holly

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... de-humanizing humanity.

Genome Editing with CRISPR-Cas9
  https://www.youtube.com/watch?v=2pp17E4E-O8

This animation depicts the CRISPR-Cas9 method for genome editing – a powerful new technology with many applications in biomedical research, including the potential to treat human genetic disease. Feng Zhang, a leader in the development of this technology, is a faculty member at MIT, an investigator at the McGovern Institute for Brain Research, and a core member of the Broad Institute. Further information can be found on Prof.
Zhang’s website at http://zlab.mit.edu



~~~ ooo ~~~

BRAVE NEW WORLD
GENE-EDITING SCIENTISTS READY TO PLAY GOD

'You're only limited by your imagination'
DOUGLAS ERNST

Quote
“The technique is revolutionary, and like all revolutions, it’s perilous,” writer Amy Maxmen said. “It could at last allow genetics researchers to conjure everything anyone has ever worried they would – designer babies, invasive mutants, species-specific bioweapons, and a dozen other apocalyptic sci-fi tropes. It brings with it all-new rules for the practice of research in the life sciences. But no one knows what the rules are – or who will be the first to break them.”

  http://www.wnd.com/2015/10/gene-editing-scientists-ready-to-play-god/
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #1 on: November 02, 2015, 07:11:03 am »

... brain-numbed University hacks, high school
science teachers, raging apocalyptic terrorists,
drugged-out DYI hackers ... even well-meaning
do-gooders out to radicate diseases ... are
monkey-wrenching the delicate balance of
God's design for life on this planet:





Here's a list of articles about this dangerous,
"life editing" technique. Please do read a few of
these ... including the one below.
Hell is about to break loose.


Biohackers gear up for genome editing
Amateurs are ready and able to try the CRISPR
technique for rewriting genes.

26 August 2015

A complete lack of formal scientific training has not kept Johan Sosa from dabbling with one of the most powerful molecular-biology tools to come along in decades.

Sosa has already used CRISPR, a three-year-old technology that makes targeted modifications to DNA, in test-tube experiments. Next week, he hopes to try the method in yeast and, later, in the model plant Arabidopsis thaliana.

Hailed for its simplicity and versatility, CRISPR allows scientists to make specific changes to a gene’s sequence more easily than ever before. Researchers have used CRISPR to edit genes in everything from bacteria to human embryos; the technique holds the potential to erase genetic defects from family pedigrees plagued by inherited disease, treat cancer in unprecedented ways or grow human organs in pigs. One researcher has even proposed modifying the elephant genome to produce a cold-adapted replica of the long-extinct woolly mammoth.

Such feats are beyond the reach of do-it-yourself (DIY) ‘biohackers’, a growing community of amateur biologists who often work in community laboratories, which typically charge a recurring fee for access to equipment and supplies. But CRISPR itself is not. Driven by an inventive spirit that inspires them to fiddle with yeast to alter the flavour of beer, build art installations out of bacteria or pursue serious basic-research questions, these amateurs cannot wait to try the technique.

“It’s, like, the most amazing tool ever,” says Andreas Stürmer,
a biohacker and entrepreneur who lives in Dublin.
“You could do it in your own home.”


Sosa is an IT consultant from San Jose, California, who took up biohacking as a hobby about three years ago, when he decided that he would like to grow organs — or maybe other body parts — in the lab. At first, he had no idea how unrealistic that goal was. “I just thought you take a bunch of stem cells and add stuff to them,” he says.

The challenge of manipulating living cells sank in as he began to read molecular-biology textbooks, attend seminars and teach himself laboratory techniques. He joined the BioCurious community lab in Sunnyvale, California.

Sosa is not quite sure what he will do with CRISPR once he has mastered it. He might participate in a group effort at BioCurious to engineer yeast to produce casein, a protein found in milk, as a step towards making vegan cheese. That could involve using CRISPR to learn how proteins are chemically modified in different types of yeast. “Now we have this ability to do what the major labs have been doing all this time,” he says. “It’s very exciting.”

√  CONTINUE: http://www.nature.com/news/biohackers-gear-up-for-genome-editing-1.18236
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #2 on: November 02, 2015, 09:15:23 pm »
^^^^

... oops! I didn't give the link for the list of articles:

√  http://www.nature.com/news/crispr-1.17547
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #3 on: November 08, 2015, 02:46:49 pm »

"
If any group or country wanted to develop germ warfare agents
they could use techniques like this. It would be quite
straightforward to make new pathogens this way  ...


APOCALYPSE NOW?
'GENE DRIVE' CAN QUICKLY CHANGE ENTIRE SPECIES
Scientists eager to 'bypass the rules of genetics'
DOUGLAS ERNST



The science fiction of Aldous Huxley’s “Brave New World” is quickly becoming reality.

One of biologist Ethan Bier’s graduate students at the University of California, San Diego, recently conducted an experiment on fruit flies with far-reaching implications – both beneficial and nightmarish – for humanity.

“It was one of the most astounding days in my personal scientific career. When he first showed me, I could not believe it,” Bier told Oregon Public Broadcasting on Thursday.

Graduate student Valentino Gantz’s used a technique called “gene drive” to accomplish something simple, yet profound: He forced a generation of brown fruit flies to have mostly blond offspring. Bier told the station his students were “jumping up and down” when the next generation maintained the mutation.

“I believe it’s going to transform the world of genetics, because it’s going to allow researchers to bypass the rules of genetics in many different spheres of activity. The gene drive immediately makes the organisms that carry [a desired mutation] have the characteristic and then secondly it causes them to have all their children have the same characteristic,” Bier said.


The effectiveness of the gene drive technique used by the
University of California is amplified when combined with a
method called CRISPR
, which WND reported on Oct. 29.


“We’re basically able to have a molecular scalpel for genomes. All the technologies in the past were sort of like sledgehammers. … This just gives scientists the capability do something that is incredibly powerful,” biologist Jennifer Doudna told Tech Insider Oct. 28.

http://www.wnd.com/2015/11/gene-drive-can-quickly-change-entire-species/
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #4 on: November 29, 2015, 07:25:15 pm »

"
Permitting even unambiguously therapeutic
interventions could start us down a pathway
towards non-therapeutic enhancement.”


Top biologists debate ban on gene-editing
Washington biology summit to consider ban on controversial technology
Robin McKie  Saturday 28 November 2015

Delegates at a crucial scientific summit this week are expected to debate a ban on the use of the controversial technique of gene-editing. Hundreds of the world’s leading biologists will gather in Washington to discuss the procedure, in which genes are removed from or added to human embryos.

Some researchers say gene-editing of humans could have unpredictable effects on future generations and is ethically unacceptable. They also warn that the technology could be used to create lineages of “enhanced” humans and want all work in the area halted until its implications are fully assessed.

As a result they are expected to call for a moratorium on future research at the summit, which is to be attended mostly by researchers from the UK, US and China, where gene-editing is most widely practised. But other scientists say a moratorium would be harmful. Gene-editing has the potential to rid the planet of some fatal illnesses, they argue. Academics in favour of continuing the current research programme point to the work of Chinese scientists, who earlier this year reported they had used a gene-editing procedure called Crispr to modify an aberrant gene that causes beta thalassaemia, an inherited life-threatening blood disorder. This was done in IVF embryos obtained from fertility clinics. The embryos were not implanted into women once the modifications were made, however.

√  CONTINUE:  http://www.theguardian.com/science/2015/nov/28/gene-editing-weapon-against-disease-or-ethical-nightmare
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #5 on: December 01, 2015, 06:34:00 am »


Designer babies: Do you want a math whiz
or a basketball wunderkind?

Science is moving toward designer babies, but the ethics must be sorted out, scientist says
By Guest Contributor -  11 19 15 - 9:01 am

Ethical warning bells went off in April when Chinese researchers reported they had experimented with 85 defective human embryos to try to alter genes in every cell without otherwise damaging the DNA.

They failed. In most cases, the genes were not altered at all, and in the few cases where the scientists managed to alter the genes, there were problems.

Even though the researchers had no plans to produce a live baby, their work once again raised the issue of how soon science will be able to engineer designer babies and, just as importantly, whether doing so is ethical.

Quote
“The temptation to play God and choose a child on the basis of a variety of
nonmedical considerations may become too strong for some parents,”
Schattner says. “The potential consequences are disturbing.”

http://suindependent.com/designer-babies/
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #6 on: December 01, 2015, 03:23:28 pm »

"
If mainstream scientists can’t explore heritable gene editing,
that, “... could put a damper on the best medical research
and instead drive the practice underground to black
markets and uncontrolled medical tourism.”



Experts Discuss ‘Line We Must Not Cross’
in the Realm of Gene Editing

Dec. 1, 2015   6:37am Liz Klimas

WASHINGTON (TheBlaze/AP) — Rewriting your DNA is getting closer to reality: A revolutionary technology is opening new frontiers for genetic engineering but not before the experts discuss its ethical implications in earnest.

Hundreds of scientists and ethicists from around the world are gathering in Washington this week to debate the boundaries of human gene editing, amid worry that the fast-moving research may outpace safety and ethics scrutiny.

Quote
They’re trying to grow transplantable human organs inside pigs. They’re even hatching mutant mosquitoes designed to be incapable of spreading malaria, and exploring ways to wipe out invasive species ...  altering sperm, eggs or embryos to affect future generations — has been widely regarded as a line science shouldn’t cross.

http://www.theblaze.com/stories/2015/12/01/experts-discuss-line-we-must-not-cross-in-the-realm-of-gene-editing/
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #7 on: December 02, 2015, 06:08:57 am »
... World War is breaking out over the
question of who gets to play GOD ...
and gets the power to hack the genetic
codes of life. It may be too late to stop it:



Ethicists square off over editing genes in human embryos
Reuters   By Julie Steenhuysen

WASHINGTON (Reuters) - Debate over the use of powerful new gene editing tools in human eggs, sperm and embryos grew heated on Tuesday as scientists and ethicists gathered at an international summit to discuss the technology, which has the power to change the DNA of unborn children.

Several groups have already called for restrictions on use of the technology known as CRISPR-Cas9, which has opened up new frontiers in genetic medicine because of its ability to modify genes quickly and efficiently.

Hille Haker, chair of Catholic Moral Theology at Loyola University Chicago, argued on Tuesday in favor of a two-year international ban on research that involves changing human reproductive cells, also known as germline cells. Such changes would be passed on to offspring.

"
Some scientists believe it is already too late to ban
any use of the technology in human reproductive cells
because the technology is easily accessible and in
widespread use
in many labs.


Quote
But researchers and the growing field of well-funded start-up companies that hope to commercialize the technology are clearly worried about possible regulations. Two of those companies, Intellia Therapeutics and CRISPR Therapeutics, issued a joint statement on Tuesday pledging not to use the new tools to edit human eggs, sperm or embryos.

  https://ca.news.yahoo.com/ethicists-square-off-over-editing-genes-human-embryos-004608840--finance.html
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Offline decemberfellow

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Re: clustered regularly interspaced short palindromic repeats
« Reply #8 on: December 02, 2015, 10:27:37 am »
I think its already been put in practice, just look at the lame brains running things.
Rev21:4
And God shall wipe away all tears from their eyes; and there shall be no more death, neither sorrow, nor crying, neither shall there be any more pain: for the former things are passed away.


Who am I
 https://www.youtube.com/watch?v=v7Fk6dt_uHo

Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #9 on: December 26, 2015, 10:13:12 am »
... at least for now.

"
Different people have different characters ...
We want to keep this diversity. We really don't
want the entire society to become one billion Einsteins."


'We Won't Make Frankensteins,'
Cloning Giant Boyalife's CEO Says

by DAVID LOM and ERIC BACULINAO

BEIJING — The head of a Chinese firm that is building the world's biggest animal cloning factory has vowed not to use the technology on people — for now, at least.

Biotech company Boyalife Group's $30 million facility in the coastal city of Tianjin will produce embryos of cattle as well as racehorses and contraband-sniffing dogs when it becomes operational next year.

"No, we don't do human cloning, we won't make Frankensteins," said Dr. Xu Xiaochun, its chief executive. "The technology we have is very advanced ... [but if uncontrolled] technology can also do damage ... Every technology has to have a boundary."

√ w/VIDEO: http://www.nbcnews.com/news/china/we-won-t-make-frankensteins-cloning-giant-boyalife-s-ceo-n480891
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #10 on: January 11, 2016, 06:21:01 am »
“The specter of an intelligent mouse stuck in a
laboratory somewhere screaming ‘I want to get out’
would be very troubling to people.”


Human-Animal Chimeras Are Gestating
on U.S. Research Farms

A radical new approach to generating human organs
is to grow them inside pigs or sheep.

By Antonio Regalado on January 6, 2016


Braving a funding ban put in place by America’s top health agency, some U.S. research centers are moving ahead with attempts to grow human tissue inside pigs and sheep with the goal of creating hearts, livers, or other organs needed for transplants.

The effort to incubate organs in farm animals is ethically charged because it involves adding human cells to animal embryos in ways that could blur the line between species.

Last September, in a reversal of earlier policy, the National Institutes of Health announced it would not support studies involving such “human-animal chimeras” until it had reviewed the scientific and social implications more closely.

The agency, in a statement, said it was worried about the chance that animals’ “cognitive state” could be altered if they ended up with human brain cells.

Quote
The experiments rely on a cutting-edge fusion of technologies, including recent breakthroughs in stem-cell biology and gene-editing techniques. By modifying genes, scientists can now easily change the DNA in pig or sheep embryos so that they are genetically incapable of forming a specific tissue. Then, by adding stem cells from a person, they hope the human cells will take over the job of forming the missing organ, which could then be harvested from the animal for use in a transplant operation.

The worry is that the animals might turn out to be a little too human for comfort, say ending up with human reproductive cells, patches of people hair, or just higher intelligence. “We are not near the island of Dr. Moreau, but science moves fast."

√ CONTINUE: http://static.infowars.com/ppcomforum/Themes/default/images/bbc/italicize.gif
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #11 on: January 13, 2016, 04:54:47 pm »
IVF: First genetically-modified human embryos
'could be created in Britain within weeks'

Steve Connor

The first genetically-modified human embryos could be created in Britain within weeks according to the scientists who are about to learn whether their research proposal has been approved by the fertility watchdog.

Although it will be illegal to allow the embryos to live beyond 14 days, and be implanted into the womb, the researchers accepted that the research could one day lead to the birth of the first GM babies should the existing ban be lifted for medical reasons.

A licence application to edit the genes of “spare” IVF embryos for research purposes only is to be discussed on 14 January by the Human Fertilisation and Embryology Authority (HFEA), with final approval likely to be given this month.

Quote
She denied that the research project will lead down a “slippery slope” to the creation of genetically modified “designer babies”, which is the argument used by many who oppose the experiment.

“Because in the UK there are very tight regulations in this area, it would be completely illegal to move in that direction. Our research is in line with what is allowed an in-keeping in the UK since 2009 which is purely for research purposes,” Dr Niakin said.
(ED: blah, blah, blah.)

http://www.independent.co.uk/news/science/ivf-first-genetically-modified-human-embryos-could-be-created-in-britain-within-weeks-a6810506.html
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #12 on: March 31, 2016, 05:28:45 pm »

... hacking life.


“Unit now it would take years to build these types
of circuits. Now you just hit the button and immediately
get a DNA sequence to test.” 


Living cells ‘hacked’ and hijacked by MIT
Sarah Knapton, science editor - 31 MARCH 2016

Scientists at MIT have proven they can ‘hack’ living cells and programme them to carry out new tasks.

In the same way that computer language tells a machine how to operate, researchers have shown it is possible to write DNA ‘code’ and insert it into bacteria to alter how they function.

They hope that one day cells could be programmed so they could release cancer drugs on encountering a tumour, or allow plants to fight back with insecticide when a pest comes near.

“It is literally a programming language for bacteria,” said Christopher Voigt, an MIT professor of biological engineering.

“You use a text-based language, just like you’re programming a computer. Then you take that text and you compile it and it turns it into a DNA sequence that you put into the cell, and the circuit runs inside the cell.”

√ CONTINUE:  http://www.telegraph.co.uk/science/2016/03/31/living-cells-hacked-and-hijacked-by-mit/
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #13 on: May 19, 2016, 06:09:14 am »

... more damn fools playing God:

"We're not trying to make a chimera just because we
want to see some kind of monstrous creature, we're
doing this for a biomedical purpose."


In Search For Cures, Scientists Create Embryos
That Are Both Animal And Human

May 18, 2016

A handful of scientists around the United States are trying to do something that some people find disturbing: make embryos that are part human, part animal.

The researchers hope these embryos, known as chimeras, could eventually help save the lives of people with a wide range of diseases.

One way would be to use chimera embryos to create better animal models to study how human diseases happen and how they progress.

Perhaps the boldest hope is to create farm animals that have human organs that could be transplanted into terminally ill patients.

But some scientists and bioethicists worry the creation of these interspecies embryos crosses the line. "You're getting into unsettling ground that I think is damaging to our sense of humanity," says Stuart Newman, a professor of cell biology and anatomy at the New York Medical College.

The experiments are so sensitive that the National Institutes of Health has imposed a moratorium on funding them while officials explore the ethical issues they raise.

Nevertheless, a small number of researchers are pursuing the work with private funding. They hope the results will persuade the NIH to lift the moratorium.

Quote
"If you have pigs with partly human brains you would have animals that might actually have consciousness like a human," Newman says. "It might have human-type needs. We don't really know."

√ RADIO SHOW: http://www.npr.org/sections/health-shots/2016/05/18/478212837/in-search-for-cures-scientists-create-embryos-that-are-both-animal-and-human
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #14 on: June 01, 2016, 12:12:47 pm »
... a simple little video is scary as HELL!

The Genetic Tool That Will Modify Humanity
Crispr allows scientists to control the blueprints of life, for better or worse.
Tom Randall  June 1, 2016

Quote
Scientists can use it to manipulate the genes of any living creature with astonishing ease. Its initial applications have been to target genetic disease, modify foods, and develop new drugs. What comes next is up to us.

√ w/VIDEO: http://www.bloomberg.com/news/articles/2016-06-01/the-genetic-tool-that-will-modify-humanity
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #15 on: June 07, 2016, 09:41:47 pm »
... is this the world you want to live in?
Customizing life for our own whims?
We must have LEADERS who outlaw these
blasphemous and dangerous practices ...
and jail ANYONE involved!

... and it's NOT just 'hair color' ... it's ANY TRAIT!

Sheep today = Humans tomorrow.


World’s first ‘spotty dog' sheep created using genetic
technique which paves way for pets with customised hair colour


Scientists have bred the world's first spotty sheep that look like "cows" and "spotty dogs" in a controversial genetic engineering experiement.

The genetically modified animals are the brainchild of Liu Mingjun - chief researcher at the state-run Xinjiang Animal Husbandry Research Institute.

He says the lambs, which were born in March using Clustered regularly interspaced short palindromic repeats (CRISPR) technology, “have become our lovely pets,” and pave the way for dye-free wool and pets with customised fur.

It is also believed the modified animals could assist with clinical research and supplying animal organs for transplant to human patients.

However, the experiment has caused fears that CRISPR could be used to create designer babies.

CRISPR/Cas9 is an immensely powerful technique invented three years ago which allows DNA to be "cut and pasted" using molecular "scissors".

It could lead to huge leaps forward in science and medicine, but critics have warned that the pace of change is too fast.

Quote
British scientists began research using CRISPR earlier this year on embryos after The Human Fertilisation and Embryology Authority (HFEA) regulator approved a licence to use gene editing in research.

√ CONTINUE: http://www.mirror.co.uk/news/weird-news/worlds-first-spotty-dog-sheep-8135231
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Offline Jackson Holly

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Re: clustered regularly interspaced short palindromic repeats
« Reply #16 on: November 26, 2018, 07:05:05 pm »
... bump!!!!

CHINA-S BABY DNA EDIT THREATENS HUMANITY

Science fiction has warned about this for decades
Jon Bowne | Infowars.com - NOVEMBER 26, 2018



Chinese scientists at the Southern University of Science and Technology in Shenzhen, China are attempting to create the first gene-edited babies.

Utilizing CRISPR, they intend on eliminating a gene known as CCR5 and creating genetically modified babies resistant to HIV, smallpox, and cholera.

But does the bad outweigh the good?

Scientists worry that once a species is modified, it is changed forever.

√ SEE VIDEO: https://www.infowars.com/chinas-baby-dna-edit-threatens-humanity/
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Offline TahoeBlue

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Re: clustered regularly interspaced short palindromic repeats - Crispr
« Reply #17 on: November 27, 2018, 12:02:46 pm »
So now it finally becomes "public" knowledge ... it's not real unless its on CNN ...

These people don't know and DO KNOW the harm they are causing

Its not what they could / should but what they CAN do ...
Behold, happy is the man whom God correcteth: therefore despise not thou the chastening of the Almighty: For he maketh sore, and bindeth up: he woundeth, and his hands make whole ; He shall deliver thee in six troubles: yea, in seven there shall no evil touch thee. - Job 5