No, I think we can defeat them, but not with handguns, and (perhaps) not with violence at all.
Handguns like pistols? No. Rifles? Yes. The US have used all theyre millitary might against afghanistan and iraq exept the use of weapons of mass destruction, and yet they are pulling out and theyre enemies are winning. I see no C-130's winning the day there. And the technology the talibans use are far below what most americans have access too.
The fact is, if the government has no reason to fear its people, it has no reason to listen to them. One of the first signs of a totalitarian regime is that your leaders start to resist you having firearms. Firearms make you less dependent on the government and in positition to resist the plans they have for you, they dont want that. Power corrupts, and its a constant struggle to obtain balance between the people and theyre servants, that have now made themselves rulers. People belive in the constitiution, free speech and democracy. Do you? Well the constitution is not worth the paper its written on if the people does not have the means to put force behind the words that are written there.
In europe, we dont have any 2 amendment. I think you know what that has resulted in here. If it wasnt for the US and theyre help in bringing that plague to an end, we would be invaded by the soviet union and to this day look something like north-korea.